Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors

Reactive oxygen species (ROS) can cause cellular damage and promote cancer development. Besides such harmful consequences of overproduction of ROS, all cells utilize ROS for signaling purposes and stabilization of cell homeostasis. In particular, the latter is supported by the NADPH oxidase 4 (Nox4)...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Helfinger, Valeska, Freiherr von Gall, Florian, Henke, Nina, Kunze, Michael M., Schmid, Tobias, Rezende, Flavia, Heidler, Juliana, Wittig, Ilka, Radeke, Heinfried H., Marschall, Viola, Anderson, Karen, Shah, Ajay M., Fulda, Simone, Brüne, Bernhard, Brandes, Ralf P., Schröder, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980388/
https://ncbi.nlm.nih.gov/pubmed/33836590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020152118
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