CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

The NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constitutively active and Nox5 is directly activated by c...

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Bibliographische Detailangaben
Veröffentlicht in:Redox Biol
Hauptverfasser: Prior, Kim-Kristin, Leisegang, Matthias S., Josipovic, Ivana, Löwe, Oliver, Shah, Ajay M., Weissmann, Norbert, Schröder, Katrin, Brandes, Ralf P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021817/
https://ncbi.nlm.nih.gov/pubmed/27614387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.08.013
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