CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

The NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constitutively active and Nox5 is directly activated by c...

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Vydáno v:Redox Biol
Hlavní autoři: Prior, Kim-Kristin, Leisegang, Matthias S., Josipovic, Ivana, Löwe, Oliver, Shah, Ajay M., Weissmann, Norbert, Schröder, Katrin, Brandes, Ralf P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021817/
https://ncbi.nlm.nih.gov/pubmed/27614387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.08.013
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