Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20–50 years after exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomi...

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Publicado en:Nat Commun
Main Authors: Zhang, Min, Luo, Jin-Li, Sun, Qianqian, Harber, James, Dawson, Alan G., Nakas, Apostolos, Busacca, Sara, Sharkey, Annabel J., Waller, David, Sheaff, Michael T., Richards, Cathy, Wells-Jordan, Peter, Gaba, Aarti, Poile, Charlotte, Baitei, Essa Y., Bzura, Aleksandra, Dzialo, Joanna, Jama, Maymun, Le Quesne, John, Bajaj, Amrita, Martinson, Luke, Shaw, Jacqui A., Pritchard, Catrin, Kamata, Tamihiro, Kuse, Nathaniel, Brannan, Lee, De Philip Zhang, Pan, Yang, Hongji, Griffiths, Gareth, Wilson, Gareth, Swanton, Charles, Dudbridge, Frank, Hollox, Edward J., Fennell, Dean A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979861/
https://ncbi.nlm.nih.gov/pubmed/33741915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21798-w
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