Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20–50 years after exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Min, Luo, Jin-Li, Sun, Qianqian, Harber, James, Dawson, Alan G., Nakas, Apostolos, Busacca, Sara, Sharkey, Annabel J., Waller, David, Sheaff, Michael T., Richards, Cathy, Wells-Jordan, Peter, Gaba, Aarti, Poile, Charlotte, Baitei, Essa Y., Bzura, Aleksandra, Dzialo, Joanna, Jama, Maymun, Le Quesne, John, Bajaj, Amrita, Martinson, Luke, Shaw, Jacqui A., Pritchard, Catrin, Kamata, Tamihiro, Kuse, Nathaniel, Brannan, Lee, De Philip Zhang, Pan, Yang, Hongji, Griffiths, Gareth, Wilson, Gareth, Swanton, Charles, Dudbridge, Frank, Hollox, Edward J., Fennell, Dean A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979861/
https://ncbi.nlm.nih.gov/pubmed/33741915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21798-w
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