Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Advanced non-small-cell lung cancer (NSCLC) patients with EGFR T790M-positive tumours benefit from osimertinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Here we show that the size of the EGFR T790M-positive clone impacts response to osimertinib. T790M subclonality, a...

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Udgivet i:Nat Commun
Main Authors: Vaclova, Tereza, Grazini, Ursula, Ward, Lewis, O’Neill, Daniel, Markovets, Aleksandra, Huang, Xiangning, Chmielecki, Juliann, Hartmaier, Ryan, Thress, Kenneth S., Smith, Paul D., Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979775/
https://ncbi.nlm.nih.gov/pubmed/33741979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22057-8
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