A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum para...

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Pubblicato in:Nat Commun
Autori principali: Coelho, Camila H., Tang, Wai Kwan, Burkhardt, Martin, Galson, Jacob D., Muratova, Olga, Salinas, Nichole D., Alves e Silva, Thiago Luiz, Reiter, Karine, MacDonald, Nicholas J., Nguyen, Vu, Herrera, Raul, Shimp, Richard, Narum, David L., Byrne-Steele, Miranda, Pan, Wenjing, Hou, Xiaohong, Brown, Brittany, Eisenhower, Mary, Han, Jian, Jenkins, Bethany J., Doritchamou, Justin Y. A., Smelkinson, Margery G., Vega-Rodríguez, Joel, Trück, Johannes, Taylor, Justin J., Sagara, Issaka, Healy, Sara A., Renn, Jonathan P., Tolia, Niraj H., Duffy, Patrick E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979743/
https://ncbi.nlm.nih.gov/pubmed/33741942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21955-1
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