Dynamic Regulation of Tfh Selection During the Germinal Center Reaction

The germinal center is a dynamic microenvironment wherein B cells expressing high affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting numbers of T follicular helper cells (1,2). Although much is known about the mechanisms that control B cell sel...

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Udgivet i:Nature
Main Authors: Merkenschlager, Julia, Finkin, Shlomo, Ramos, Victor, Kraft, Julian, Cipolla, Melissa, Nowosad, Carla R., Hartweger, Harald, Zhang, Wenzhu, Olinares, Paul Dominic B., Gazumyan, Anna, Oliveira, Thiago Y., Chait, Brian T., Nussenzweig, Michel C.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979475/
https://ncbi.nlm.nih.gov/pubmed/33536617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03187-x
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