GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Immune escape mechanisms employed by neuroblastoma (NB) cells include secretion of immunosuppressive factors disrupting effective antitumor immunity. The use of cellular therapy to treat solid tumors needs to be implemented. Killing activity of anti-GD2 Chimeric Antigen Receptor (CAR) T or natural k...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Caforio, Matteo, Sorino, Cristina, Caruana, Ignazio, Weber, Gerrit, Camera, Antonio, Cifaldi, Loredana, De Angelis, Biagio, Del Bufalo, Francesca, Vitale, Alessia, Goffredo, Bianca Maria, De Vito, Rita, Fruci, Doriana, Quintarelli, Concetta, Fanciulli, Maurizio, Locatelli, Franco, Folgiero, Valentina
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2021
Sujets:
Immunotherapy Biomarkers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978286/
https://ncbi.nlm.nih.gov/pubmed/33737337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001502
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires