GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Immune escape mechanisms employed by neuroblastoma (NB) cells include secretion of immunosuppressive factors disrupting effective antitumor immunity. The use of cellular therapy to treat solid tumors needs to be implemented. Killing activity of anti-GD2 Chimeric Antigen Receptor (CAR) T or natural k...

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書目詳細資料
發表在:J Immunother Cancer
Main Authors: Caforio, Matteo, Sorino, Cristina, Caruana, Ignazio, Weber, Gerrit, Camera, Antonio, Cifaldi, Loredana, De Angelis, Biagio, Del Bufalo, Francesca, Vitale, Alessia, Goffredo, Bianca Maria, De Vito, Rita, Fruci, Doriana, Quintarelli, Concetta, Fanciulli, Maurizio, Locatelli, Franco, Folgiero, Valentina
格式: Artigo
語言:Inglês
出版: BMJ Publishing Group 2021
主題:
Immunotherapy Biomarkers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978286/
https://ncbi.nlm.nih.gov/pubmed/33737337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001502
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