Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

[Image: see text] The UbiD family of reversible (de)carboxylases depends on the recently discovered prenylated-FMN (prFMN) cofactor for activity. The model enzyme ferulic acid decarboxylase (Fdc1) decarboxylates unsaturated aliphatic acids via a reversible 1,3-cycloaddition process. Protein engineer...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Payne, Karl A. P., Marshall, Stephen A., Fisher, Karl, Rigby, Stephen E. J., Cliff, Matthew J., Spiess, Reynard, Cannas, Diego M., Larrosa, Igor, Hay, Sam, Leys, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7976604/
https://ncbi.nlm.nih.gov/pubmed/33763291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c05042
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