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Enzymatic control of cycloadduct conformation ensures reversible 1,3 dipolar cycloaddition in a prFMN dependent decarboxylase

The UbiD enzyme plays an important role in bacterial ubiquinone (coenzyme Q) biosynthesis. It belongs to a family of reversible decarboxylases that interconvert propenoic or aromatic acids with the corresponding alkenes or aromatic compounds using a prenylated flavin (prFMN) cofactor. This cofactor...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Bailey, Samuel S., Payne, Karl A. P., Saaret, Annica, Marshall, Stephen A., Gostimskaya, Irina, Kosov, Iaroslav, Fisher, Karl, Hay, Sam, Leys, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817360/
https://ncbi.nlm.nih.gov/pubmed/31527849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0324-8
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