Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDA mouse model and show that neoantigen expression is required for intratumoral T cell accumulation and response to immune checkpoint blockade. By generating a peptide:MHC tetramer, we identify that PD...

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Udgivet i:Cell Rep
Main Authors: Burrack, Adam L., Spartz, Ellen J., Raynor, Jackson F., Wang, Iris, Olson, Margaret, Stromnes, Ingunn M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7975822/
https://ncbi.nlm.nih.gov/pubmed/31433988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.059
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