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PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregu...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Azad, Abul, Yin Lim, Su, D'Costa, Zenobia, Jones, Keaton, Diana, Angela, Sansom, Owen J, Kruger, Philipp, Liu, Stanley, McKenna, W Gillies, Dushek, Omer, Muschel, Ruth J, Fokas, Emmanouil
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286375/
https://ncbi.nlm.nih.gov/pubmed/27932443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606674
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