PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregu...

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Detaylı Bibliyografya
Yayımlandı:EMBO Mol Med
Asıl Yazarlar: Azad, Abul, Yin Lim, Su, D'Costa, Zenobia, Jones, Keaton, Diana, Angela, Sansom, Owen J, Kruger, Philipp, Liu, Stanley, McKenna, W Gillies, Dushek, Omer, Muschel, Ruth J, Fokas, Emmanouil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286375/
https://ncbi.nlm.nih.gov/pubmed/27932443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606674
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