Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia

SIMPLE SUMMARY: Acute Myeloid Leukemia is an aggressive disease with poor outcomes. New targeted therapies that can boost the effects of currently used chemotherapy medications without added toxicity are needed. Targeting an overactive kinase, called the protein Kinase CK2 in AML, helps leukemia cel...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Klink, Morgann, Rahman, Mohammad Atiqur, Song, Chunhua, Dhanyamraju, Pavan Kumar, Ehudin, Melanie, Ding, Yali, Steffens, Sadie, Bhadauria, Preeti, Iyer, Soumya, Aliaga, Cesar, Desai, Dhimant, Huang, Suming, Claxton, David, Sharma, Arati, Gowda, Chandrika
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7975325/
https://ncbi.nlm.nih.gov/pubmed/33807974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13051127
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