HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias

T-cell and B-cell acute lymphoblastic leukemias (T-ALL, B-ALL) are aggressive hematological malignancies characterized by an accumulation of immature T- or B-cells. Although patient outcomes have improved, novel targeted therapies are needed to reduce the intensity of chemotherapy and improve the pr...

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Publicado no:Blood Cancer J
Main Authors: Mshaik, Rony, Simonet, John, Georgievski, Aleksandra, Jamal, Layla, Bechoua, Shaliha, Ballerini, Paola, Bellaye, Pierre-Simon, Mlamla, Zandile, Pais de Barros, Jean-Paul, Geissler, Audrey, Francin, Pierre-Jean, Girodon, François, Garrido, Carmen, Quéré, Ronan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973815/
https://ncbi.nlm.nih.gov/pubmed/33737511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00450-2
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