Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats

Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising outcomes in primary brain cancer. However, it is unclear how...

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Pubblicato in:Sci Rep
Autori principali: Nehra, Geetika, Andrews, Shannon, Rettig, Joan, Gould, Michael N., Haag, Jill D., Howard, Steven P., Thorne, Robert G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973779/
https://ncbi.nlm.nih.gov/pubmed/33737566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85293-4
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