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In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations
Liver and kidney uptake and antisense activity is studied for a series of Locked Nucleic Acid (LNA) oligonucleotides with fully stereo-defined, internucleoside linkages. These stereo-specific phosphorothioates are made with a newly developed synthesis method and are being analyzed both theoretically...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7973520/ https://ncbi.nlm.nih.gov/pubmed/33737567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85453-6 |
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