Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis

Mice lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity in the distal nephron and develop salt-sensitive hypertension. This indicates a functional link between Cx30 and ENaC, which remains incompletely understood. Here, we explore the effect of Cx30 on ENaC functi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ilyaskin, Alexandr V., Korbmacher, Christoph, Diakov, Alexei
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973139/
https://ncbi.nlm.nih.gov/pubmed/33577799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100404
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