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The evolutionary origin of the universal distribution of mutation fitness effect

An intriguing fact long defying explanation is the observation of a universal exponential distribution of beneficial mutations in fitness effect for different microorganisms. To explain this effect, we use a population model including mutation, directional selection, linkage, and genetic drift. The...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Barlukova, Ayuna, Rouzine, Igor M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971868/
https://ncbi.nlm.nih.gov/pubmed/33684109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008822
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