Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases

The function of Sprouty2 (Spry2) in T cells is unknown. Using 2 different (inducible and T cell–targeted) knockout mouse strains, we found that Spry2 positively regulated extracellular signal-regulated kinase 1/2 (ERK1/2) signaling by modulating the activity of LCK. Spry2(−/−) CD4(+) T cells were un...

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Publicado en:PLoS Biol
Main Authors: Sripada, Anand, Sirohi, Kapil, Michalec, Lidia, Guo, Lei, McKay, Jerome T., Yadav, Sangya, Verma, Mukesh, Good, James, Rollins, Donald, Gorska, Magdalena M., Alam, Rafeul
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971865/
https://ncbi.nlm.nih.gov/pubmed/33684096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001063
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