IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease within the spondyloarthritis spectrum. IL-12p40/IL-23p40 blockade reduces PsA disease activity, but its impact on synovial inflammation remains unclear. Objectives: To investigate the cellular and molecular pathways affect...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fiechter, Renée H., de Jong, Henriëtte M., van Mens, Leonieke J. J., Fluri, Inka A., Tas, Sander W., Baeten, Dominique L. P., Yeremenko, Nataliya G., van de Sande, Marleen G. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971179/
https://ncbi.nlm.nih.gov/pubmed/33746955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.611656
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