IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease within the spondyloarthritis spectrum. IL-12p40/IL-23p40 blockade reduces PsA disease activity, but its impact on synovial inflammation remains unclear. Objectives: To investigate the cellular and molecular pathways affect...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Fiechter, Renée H., de Jong, Henriëtte M., van Mens, Leonieke J. J., Fluri, Inka A., Tas, Sander W., Baeten, Dominique L. P., Yeremenko, Nataliya G., van de Sande, Marleen G. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971179/
https://ncbi.nlm.nih.gov/pubmed/33746955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.611656
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