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IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt

Background: Psoriatic arthritis (PsA) is a chronic inflammatory joint disease within the spondyloarthritis spectrum. IL-12p40/IL-23p40 blockade reduces PsA disease activity, but its impact on synovial inflammation remains unclear. Objectives: To investigate the cellular and molecular pathways affect...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Fiechter, Renée H., de Jong, Henriëtte M., van Mens, Leonieke J. J., Fluri, Inka A., Tas, Sander W., Baeten, Dominique L. P., Yeremenko, Nataliya G., van de Sande, Marleen G. H.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971179/
https://ncbi.nlm.nih.gov/pubmed/33746955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.611656
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