A novel class of negative allosteric modulators of NMDA receptor function

NMDA receptors mediate a slow Ca(2+)-permeable component of excitatory synaptic transmission, and are involved in numerous normal brain functions including learning and memory. NMDA receptor over-activation can lead to cell death and abnormal excitation in ischemia associated with stroke, traumatic...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Katzman, Brooke M., Perszyk, Riley E., Yuan, Hongjie, Tahirovic, Yesim Altas, Sotimehin, Ayodeji E., Traynelis, Stephen F., Liotta, Dennis C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971076/
https://ncbi.nlm.nih.gov/pubmed/26525866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.046
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