Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method

Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer. Poziotinib is currently under clinical investigation, and understanding its drug-drug interactions is extremely important for its future develo...

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Foilsithe in:Front Pharmacol
Main Authors: Wang, Jinhui, Chen, Feifei, Jiang, Hui, Xu, Jia, Meng, Deru, Geng, Peiwu, Dai, Dapeng, Hu, Jingbo, Zhou, Yunfang, Zhou, Quan, Wang, Shuanghu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970697/
https://ncbi.nlm.nih.gov/pubmed/33746741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.593518
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