Reduced spontaneous itch in mouse models of cholestasis

Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in cholestatic patients, but the pathophysiology is unclear. To study pruritus in mice, we measured scratch activity in cholestatic Atp8b1 mutant mice, a...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Langedijk, Jacqueline, Bolier, Ruth, Tolenaars, Dagmar, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Waart, Dirk, Beuers, Ulrich, Bosma, Piter, Elferink, Ronald Oude
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969945/
https://ncbi.nlm.nih.gov/pubmed/33731871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85660-1
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