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Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
Preclinical studies in mice and non-human primates showed that AAV serotype 5 provides efficient liver transduction and as such seems a promising vector for liver directed gene therapy. An advantage of AAV5 compared to serotype 8 already shown to provide efficient correction in a phase 1 trial in pa...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873922/ https://ncbi.nlm.nih.gov/pubmed/24386104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082597 |
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