Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling

Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism. In models of FGF23 excess, renal deoxyribonuclease 1 (Dnase1) mRNA expression is downregulated. Dnase-1 is an endonuclease which binds monomeric actin. We investigated whether F...

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Publicado no:Sci Rep
Main Authors: Egli-Spichtig, Daniela, Zhang, Martin Y. H., Li, Alfred, Pastor Arroyo, Eva Maria, Hernando, Nati, Wagner, Carsten A., Chang, Wenhan, Perwad, Farzana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969776/
https://ncbi.nlm.nih.gov/pubmed/33731726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84735-3
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