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Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension

Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role. Previously, we identified a role of PaCLPP, a mitochondrial matrix protease, in the control of the mitochondrial energy metabolism, aging, and...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Heinz, Daniela, Krotova, Evgeniia, Hamann, Andrea, Osiewacz, Heinz D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969656/
https://ncbi.nlm.nih.gov/pubmed/33748105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.616520
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