Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

Trastuzumab emtansine (T-DM1), an antibody-drug conjugate consisted of the HER2-targeted monoclonal antibody trastuzumab and the tubulin inhibitor emtansine, has shown potent therapeutic value in HER2-positive breast cancer (BC). However, a clinical trial indicated that T-DM1 exerts a limited effect...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Zhang, Jinghui, Fan, Jiajun, Zeng, Xian, Nie, Mingming, Chen, Wei, Wang, Yichen, Luan, Jingyun, Zhu, Zeguo, Chang, Xusheng, Ju, Dianwen, Feng, Li, Yin, Kai
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969610/
https://ncbi.nlm.nih.gov/pubmed/33731670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03349-1
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