Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

We use single-molecule techniques to characterize the dynamics of prokaryotic DNA repair by non-homologous end-joining (NHEJ), a system comprised only of the dimeric Ku and Ligase D (LigD). The Ku homodimer alone forms a ∼2 s synapsis between blunt DNA ends that is increased to ∼18 s upon addition o...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Öz, Robin, Wang, Jing L, Guerois, Raphael, Goyal, Gaurav, KK, Sriram, Ropars, Virginie, Sharma, Rajhans, Koca, Firat, Charbonnier, Jean-Baptiste, Modesti, Mauro, Strick, Terence R, Westerlund, Fredrik
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969030/
https://ncbi.nlm.nih.gov/pubmed/33590005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab083
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