Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

Liquid–liquid phase separation underlies the membrane-less compartmentalization of cells. Intrinsically disordered low-complexity domains (LCDs) often mediate phase separation, but how their phase behavior is modulated by folded domains is incompletely understood. Here, we interrogate the interplay...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Martin, Erik W, Thomasen, F Emil, Milkovic, Nicole M, Cuneo, Matthew J, Grace, Christy R, Nourse, Amanda, Lindorff-Larsen, Kresten, Mittag, Tanja
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969017/
https://ncbi.nlm.nih.gov/pubmed/33577679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab063
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