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Extracellular matrix density regulates the formation of tumour spheroids through cell migration

In this work, we show how the mechanical properties of the cellular microenvironment modulate the growth of tumour spheroids. Based on the composition of the extracellular matrix, its stiffness and architecture can significantly vary, subsequently influencing cell movement and tumour growth. However...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Gonçalves, Inês G., Garcia-Aznar, Jose Manuel
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968691/
https://ncbi.nlm.nih.gov/pubmed/33635856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008764
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