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Extracellular matrix density regulates the formation of tumour spheroids through cell migration

In this work, we show how the mechanical properties of the cellular microenvironment modulate the growth of tumour spheroids. Based on the composition of the extracellular matrix, its stiffness and architecture can significantly vary, subsequently influencing cell movement and tumour growth. However...

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Bibliografski detalji
Izdano u:PLoS Comput Biol
Glavni autori: Gonçalves, Inês G., Garcia-Aznar, Jose Manuel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968691/
https://ncbi.nlm.nih.gov/pubmed/33635856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008764
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