17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating...

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Publicado en:J Clin Invest
Main Authors: Frump, Andrea L., Albrecht, Marjorie, Yakubov, Bakhtiyor, Breuils-Bonnet, Sandra, Nadeau, Valérie, Tremblay, Eve, Potus, Francois, Omura, Junichi, Cook, Todd, Fisher, Amanda, Rodriguez, Brooke, Brown, R. Dale, Stenmark, Kurt R., Rubinstein, C. Dustin, Krentz, Kathy, Tabima, Diana M., Li, Rongbo, Sun, Xin, Chesler, Naomi C., Provencher, Steeve, Bonnet, Sebastien, Lahm, Tim
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968046/
https://ncbi.nlm.nih.gov/pubmed/33497359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129433
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