Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation

New therapeutic strategies against glioblastoma multiforme (GBM) are urgently needed. Signal transducer and activator of transcription 3 (STAT3), constitutively active in many GBM tumors, plays a major role in GBM tumor growth and represents a potential therapeutic target. We have documented previou...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Luo, Dingyuan, Fraga-Lauhirat, Magdalena, Millings, Jonathan, Ho, Cristella, Villarreal, Emily M, Fletchinger, Teresa C, Bonfiglio, James V, Mata, Leyda, Nemesure, Matthew D, Bartels, Lauren E, Wang, Ruixue, Rigas, Basil, Mackenzie, Gerardo G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967702/
https://ncbi.nlm.nih.gov/pubmed/30994173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz069
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