The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1

Given that glioblastoma multiforme (GBM) is associated with poor prognosis, new agents are urgently needed. We developed phospho-glycerol-ibuprofen-amide (PGIA), a novel ibuprofen derivative, and evaluated its safety and efficacy in preclinical models of GBM, and its mechanism of action using human...

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Vydáno v:Carcinogenesis
Hlavní autoři: Bartels, Lauren E., Mattheolabakis, George, Vaeth, Brandon M., LaComb, Joseph F., Wang, Ruixue, Zhi, Jizu, Komninou, Despina, Rigas, Basil, Mackenzie, Gerardo G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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Original Manuscript
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006213/
https://ncbi.nlm.nih.gov/pubmed/26905586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw017
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