Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models

We have developed a novel chemical modification of conventional nonsteroidal anti-inflammatory drugs to reduce their toxicity and enhance their efficacy. Phospho-ibuprofen [(PI) 2-(4-isobutyl-phenyl)-propionic acid-4-(diethoxy-phosphoryloxy)-butyl ester (MDC-917)], a novel derivative of ibuprofen, s...

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Bibliografske podrobnosti
Main Authors: Xie, Gang, Sun, Yu, Nie, Ting, Mackenzie, Gerardo G., Huang, Liqun, Kopelovich, Levy, Komninou, Despina, Rigas, Basil
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2011
Teme:
Metabolism, Transport, and Pharmacogenomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101013/
https://ncbi.nlm.nih.gov/pubmed/21422165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180224
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