Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice

BACKGROUND & AIMS: Non-steroidal anti-inflammatory drugs (NSAIDs) are effective cancer chemopreventive agents. However, chronic administration of NSAIDs is associated with significant side effects, mainly gastrointestinal. Given these limitations, we synthesized phospho-sulindac (P-S; OXT-328),...

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Hlavní autoři: Mackenzie, Gerardo G., Sun, Yu, Huang, Liqun, Xie, Gang, Ouyang, Nengtai, Gupta, Ramesh C., Johnson, Francis, Komninou, Despina, Kopelovich, Levy, Rigas, Basil
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949489/
https://ncbi.nlm.nih.gov/pubmed/20600034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.06.044
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