The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine

BACKGROUND AND PURPOSE: Phospho-sulindac (PS; OXT-328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored its metabolism and pharmacokinetics. EXPERIMENTAL APPROACH: PS metabolism was studied in cultured cells, liver microsomes and cytosol,...

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Detalhes bibliográficos
Main Authors: Xie, G, Nie, T, Mackenzie, GG, Sun, Y, Huang, L, Ouyang, N, Alston, N, Zhu, C, Murray, OT, Constantinides, PP, Kopelovich, L, Rigas, B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413853/
https://ncbi.nlm.nih.gov/pubmed/21955327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01705.x
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