Dual regulation of TxNIP by ChREBP and FoxO1 in liver

TxNIP (Thioredoxin-interacting protein) is considered as a potential drug target for type 2 diabetes. Although TxNIP expression is correlated with hyperglycemia and glucotoxicity in pancreatic β cells, its regulation in liver cells has been less investigated. In the current study, we aim at providin...

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Veröffentlicht in:iScience
Hauptverfasser: Noblet, Benedicte, Benhamed, Fadila, O-Sullivan, InSug, Zhang, Wenwei, Filhoulaud, Gaëlle, Montagner, Alexandra, Polizzi, Arnaud, Marmier, Solenne, Burnol, Anne-Françoise, Guilmeau, Sandra, Issad, Tarik, Guillou, Hervé, Bernard, Catherine, Unterman, Terry, Postic, Catherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966993/
https://ncbi.nlm.nih.gov/pubmed/33748706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102218
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