Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture

Gout is a common inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. This activates the macrophages into a proinflammatory state by inducing NLRP3-dependent interleukin-1β (IL-1β) secretion, resulting in neutrophil recruitment. Soluble decoy receptor 3 (...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Pan, Yi-Gen, Huang, Ming-Ting, Sekar, Ponarulselvam, Huang, Duen-Yi, Lin, Wan-Wan, Hsieh, Shie-Liang
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966727/
https://ncbi.nlm.nih.gov/pubmed/33746978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.638676
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