Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations and perturbations in lipid hom...

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Vydáno v:Nat Commun
Hlavní autoři: Schiattarella, Gabriele G., Altamirano, Francisco, Kim, Soo Young, Tong, Dan, Ferdous, Anwarul, Piristine, Hande, Dasgupta, Subhajit, Wang, Xuliang, French, Kristin M., Villalobos, Elisa, Spurgin, Stephen B., Waldman, Maayan, Jiang, Nan, May, Herman I., Hill, Theodore M., Luo, Yuxuan, Yoo, Heesoo, Zaha, Vlad G., Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966396/
https://ncbi.nlm.nih.gov/pubmed/33727534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21931-9
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