Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations and perturbations in lipid hom...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Schiattarella, Gabriele G., Altamirano, Francisco, Kim, Soo Young, Tong, Dan, Ferdous, Anwarul, Piristine, Hande, Dasgupta, Subhajit, Wang, Xuliang, French, Kristin M., Villalobos, Elisa, Spurgin, Stephen B., Waldman, Maayan, Jiang, Nan, May, Herman I., Hill, Theodore M., Luo, Yuxuan, Yoo, Heesoo, Zaha, Vlad G., Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966396/
https://ncbi.nlm.nih.gov/pubmed/33727534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21931-9
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