Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(−)/HCO(3)(−) exchanger AE2 activity through modulating the lysosomal degradation of AE2

Anion exchanger 2 (AE2) plays crucial roles in regulating cell volume homeostasis and cell migration. We found that both IRBIT and Long-IRBIT (L-IRBIT) interact with anion exchanger 2 (AE2). The interaction occurred between the conserved AHCY-homologous domain of IRBIT/L-IRBIT and the N-terminal cyt...

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Publicado no:Sci Rep
Main Authors: Itoh, Ryo, Hatano, Naoya, Murakami, Momoko, Mitsumori, Kosuke, Kawasaki, Satoko, Wakagi, Tomoka, Kanzaki, Yoshino, Kojima, Hiroyuki, Kawaai, Katsuhiro, Mikoshiba, Katsuhiko, Hamada, Koichi, Mizutani, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966362/
https://ncbi.nlm.nih.gov/pubmed/33727633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85499-6
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