IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP(3))-binding pocket of the IP(3) receptor (IP(3)R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP(3)-binding domain. Here we show that Bcl2l10 and IRBIT interact and exert an additive inhibition...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bonneau, Benjamin, Ando, Hideaki, Kawaai, Katsuhiro, Hirose, Matsumi, Takahashi-Iwanaga, Hiromi, Mikoshiba, Katsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173324/
https://ncbi.nlm.nih.gov/pubmed/27995898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19896
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