Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology

Morbidity and mortality associated with neonatal sepsis remains a healthcare crisis. PD1(−/−) neonatal mice endured experimental sepsis, in the form of cecal slurry (CS), and showed improved rates of survival compared to wildtype (WT) counterparts. End-organ injury, particularly of the lung, contrib...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fallon, Eleanor A., Chung, Chun-Shiang, Heffernan, Daithi S., Chen, Yaping, De Paepe, Monique E., Ayala, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7965961/
https://ncbi.nlm.nih.gov/pubmed/33746973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.634529
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