Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis

We have shown that invariant natural killer T (iNKT) cells mediate sepsis-induced end-organ changes and immune responses, including macrophage bacterial phagocytosis, a finding regulated by the check point protein program cell death receptor-1 (PD-1). Furthermore, PD-1 mediates mortality in both adu...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Fallon, Eleanor A., Chun, Tristen T., Young, Whitney A., Gray, Chyna, Ayala, Alfred, Heffernan, Daithi S.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701916/
https://ncbi.nlm.nih.gov/pubmed/29209308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01469
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