Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were perf...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Boccuto, Adele, Dragoni, Filippo, Picarazzi, Francesca, Lai, Alessia, Della Ventura, Carla, Veo, Carla, Giammarino, Federica, Saladini, Francesco, Zehender, Gianguglielmo, Zazzi, Maurizio, Mori, Mattia, Vicenti, Ilaria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962015/
https://ncbi.nlm.nih.gov/pubmed/33800884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052670
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