Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were perf...

Full description

Saved in:
Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Boccuto, Adele, Dragoni, Filippo, Picarazzi, Francesca, Lai, Alessia, Della Ventura, Carla, Veo, Carla, Giammarino, Federica, Saladini, Francesco, Zehender, Gianguglielmo, Zazzi, Maurizio, Mori, Mattia, Vicenti, Ilaria
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962015/
https://ncbi.nlm.nih.gov/pubmed/33800884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052670
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items